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PlantaSYST position: Postdoctoral Researcher

Location (Dept., Institute): Molecular Biology, Institute of Biochemistry and Biology, University of Potsdam, Germany

The main area of Lena’s research is the development of Synthetic Biology tools to optimize terologous expression in the well-known, fast growing and easy to handle host Saccharomyces cerevisiae. Here, she focuses on promoter engineering studies, including optogenetics, to allow precise and parallel regulation of multiple gene expression. With this, whole biological pathways can be fine-tuned to increase the production yield of technically, pharmaceutically or medical relevant substances, like e.g. plant metabolites. Lena is also interested in studying simple plants, like the liverwort Marchantia polymorpha, to use them as chassis for pathway engineering projects.

 SELECTED PUBLICATIONS:

Machens F.,* Hochrein L.,* Mueller-Roeber, B. (2019) The AssemblX toolkit for reliable and user-friendly multi-gene assemblies. Springer Protocols - Methods in Molecular Biology (accepted).

Hochrein L., Mitchell L.A., Schulz K., Messerschmidt K., Mueller-Roeber B. (2018) L-SCRaMbLE as a tool for light-controlled Cre-mediated recombination in yeast. Nature communications. 9: 1931. https://doi.org/10.1038/s41467-017-02208-6

Hochrein L., Machens F., Messerschmidt K., Mueller-Roeber, B. (2017) PhiReX: a programmable and red light-regulated protein expression switch for yeast. Nucleic Acids Research. 45: 9193–9205. https://doi.org/10.1093/nar/gkx610

Hochrein L.*, Machens F.*, Gremmels J., Schulz K., Messerschmidt K., Mueller-Roeber, B. (2017) AssemblX: a user-friendly toolkit for rapid and reliable multi-gene assemblies. Nucleic Acids Research. 45: e80. https://doi.org/10.1093/nar/gkx034

* These authors contributed equally.

Professional links: https://www.researchgate.net/profile/Lena_Hochrein https://www.researchgate.net/profile/Lena_Hochrein

PlantaSYST has received funding from the European Union’s Horizon 2020 research and innovation programme (SGA-CSA No 664621 and No 739582 under FPA No. 664620)


Calls: H2020-WIDESPREAD-2014-2015, Topic: WIDESPREAD-1-2014: Teaming, and H2020-WIDESPREAD-2016-2017, Topic: H2020-WIDESPREAD-01-2016-2017: TeamingPhase2